GFI1B and LSD1 repress myeloid traits during megakaryocyte differentiation
Abstract The transcription factor Growth Factor Independence 1B (GFI1B) recruits Lysine Specific Demethylase 1 A (LSD1/KDM1A) to stimulate gene programs relevant for megakaryocyte and platelet biology.Inherited pathogenic GFI1B variants result in thrombocytopenia and bleeding propensities with varying intensity.Whether these affect similar gene pro